Mechanisms of carcinogenicity of trichloroethene (TCE) and tetrachloroethene (PCE)metabolites

The report reviews the literature relating to the carcinogenicity of two widely used chlorinated solvents, trichloroethene and tetrachloroethene. The weight of evidence indicates that tri- and tetrachloroethene are not genotoxic carcinogens. The use of (NOAEL) and an appropriate safety factor to determine the tolerable daily intake (TDI) is, therefore, the most appropriate that is likely to be safe for humans.