Synthesis of an Internal Standard for the Determination of Anatoxin- A in Water
Anatoxin- A is a neurotoxin, produced by blue- green algae. These algae are sometimes present in reservoir waters, leading to concern over the potential presence of anatoxin- a in drinking waters. A method for the determination of anatoxin- a in reservoir water was developed in 1993, which involves high performance liquid chromatography (HPLC) with ultraviolet (UV) detection. Its use has led to the detection of low levelsof the chemicals in some waters. It was considered that an internal standard would improve the performance of the method. Various potential internal standards were considered, and one (trideuterohomoanatoxin- a) was found to be suitable. This compound was synthesised by Cookson Chemicals, and sufficient material made available for an inter- laboratory performance testing exercise of the anatoxin- a method. Preliminary testing by WRc has shown an improvement in the performance of the method when using this internal standard.
|UKWIR Reference :- 96/DW/07/3||Published Date :- 17/04/2002|
|Retail Price (£) :- 40||ISBN :- 1 84057 060 1|